AChE-IN-5
AChE-IN-5 (compound 5) exhibits strong in vitro bioactivity against AChE/5-HT1A/SERT and exhibits good BBB permeability. AChE-IN-5 shows IC50 value 2.29 nM against AChE, EC50 value 58.6 nM against 5-HT1A and IC50 value against SERT. Orally active[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor; Cholinesterase (ChE) ; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-5.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC2=C(NC=C2CCCCN3CCN(CC3)C4=CC=C(C=C4)C(CCC5CCN(CC5)CC6=CC=CC=C6)=O)C=C1
Molecular Formula
C38H45N5O
Molecular Weight
587.80
References & Citations
[1]Li X, et al. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression. Eur J Med Chem. 2022;229:114045.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; AChE
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