RAF-IN-1
RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].
Product Specifications
CAS Number
[2695505-82-7]
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/raf-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC4=C(C(NC5(CCOCC5)O4)=O)C=C3)=C2
Molecular Formula
C26H22F3N3O4
Molecular Weight
497.47
References & Citations
[1]Zhao P, et al. Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers. Eur J Med Chem. 2022;228:114040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; C-Raf
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