Glucosylceramide synthase-IN-3

Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 16 nM for human GCS.Glucosylceramide synthase-IN-3 can be used for Gaucher's disease research[1][2].

Product Specifications

CAS Number

[3029827-91-3]

UNSPSC

12352005

Target

Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glucosylceramide-synthase-in-3.html

Concentration

10mM

Purity

99.11

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[C@H]1CN2CCC1CC2)NC3=CC=CC4=C3N=C(O4)C5=CC=C(C=C5)F

Molecular Formula

C21H20FN3O3

Molecular Weight

381.40

References & Citations

[1]Mali Cosden, et al. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiol Dis. 2021 Nov;159:105507.|[2]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65 (5) :4270-4290