HCAII-IN-7

HCAII-IN-7 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor with Kis of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcaii-in-7.html

Solubility

10 mM in DMSO

Smiles

NS(=O)(C1=CC=C(C=C1)C(N2CCN(C[C@H]2CCO)CC3=CC=CC=C3)=O)=O

Molecular Formula

C20H25N3O4S

Molecular Weight

403.50

References & Citations

[1]Chiaramonte N, et al. 2- (2-Hydroxyethyl) piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022;228:114026.