HCAII-IN-6
HCAII-IN-6 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor with a Ki of 4.4 nM. hCAII-IN-6 also inhibits other hCAs isoforms I, IV and IX, with Ki values of 9.2 nM, 480.2 nM and 14.7 nM, respectively. hCAII-IN-6 can be used for glaucoma research[1].
Product Specifications
CAS Number
3067465-38-4
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/hcaii-in-6.html
Solubility
10 mM in DMSO
Smiles
NS(=O)(C1=CC=C(C=C1)C(N2CCN(C[C@@H]2CCO)CC3=CC=CC=C3)=O)=O
Molecular Formula
C20H25N3O4S
Molecular Weight
403.50
References & Citations
[1]Niccolò Chiaramonte, et al. 2- (2-Hydroxyethyl) piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022 Jan 15;228:114026.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II
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