hCAII-IN-6
Product Specifications
UNSPSC Description
hCAII-IN-6 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor with a Ki of 4.4 nM. hCAII-IN-6 also inhibits other hCAs isoforms I, IV and IX, with Ki values of 9.2 nM, 480.2 nM and 14.7 nM, respectively. hCAII-IN-6 can be used for glaucoma research[1].
Target Antigen
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/hcaii-in-6.html
Solubility
10 mM in DMSO
Smiles
NS(=O)(C1=CC=C(C=C1)C(N2CCN(C[C@@H]2CCO)CC3=CC=CC=C3)=O)=O
Molecular Weight
403.50
References & Citations
[1]Niccolò Chiaramonte, et al. 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022 Jan 15;228:114026.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144264/hCAII-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144264/
Clinical Information
No Development Reported
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