3CPLro-IN-2
3CPLro-IN-2 (compound C1) is a potent and orally active inhibitor of SARS-CoV-2 3CLpro with an IC50 and Ki of 1.55 and 6.09 μM, respectively. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive agent target for fighting COVID-19[1].
Product Specifications
CAS Number
2758278-51-0
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/3cplro-in-2.html
Solubility
10 mM in DMSO
Smiles
OCC1CC2=C(C3=C(C=CC(C4=CC=C(C=C4)Br)=C31)O)C=CC=C2C5=NC=CC(C6=CC=CC=C6)=C5
Molecular Formula
C32H24BrNO2
Molecular Weight
534.44
References & Citations
[1]Zhang JW, et al. Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19. Eur J Med Chem. 2022;228:114030.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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