BRP-201
Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the research of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
Product Specifications
CAS Number
2227434-74-2
UNSPSC
12352005
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/brp-201.html
Solubility
10 mM in DMSO
Smiles
S=C1OC(C2=CC=C3C(N=C(C(C4=CC=C(CC(C)C)C=C4)C)N3CC5=CC=CC=C5Cl)=C2)=NN1
Molecular Formula
C28H27ClN4OS
Molecular Weight
503.06
References & Citations
[1]Ergül AG, et al. Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. Eur J Med Chem. 2022 Mar 5;231:114167.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9022346-01 1 g
(s) -N-Fmoc-alpha- (tetrahydro-2H-pyran-4-yl) glycine
Sign In for Pricing
View Details MBS9022346-02 5x 1 g
(s) -N-Fmoc-alpha- (tetrahydro-2H-pyran-4-yl) glycine
Sign In for Pricing
View Details 
TMAB-02009C5.5-01 100 µL
Mouse Anti-Rabbit IgG H&L Secondary Antibody-Cy5.5
Sign In for Pricing
View Details TMAB-02009C5.5-02 1 mL
Mouse Anti-Rabbit IgG H&L Secondary Antibody-Cy5.5
Sign In for Pricing
View Details 034949 200 µL
EFNA4, ID (EPH-related receptor tyrosine kinase ligand 4, LERK-4, Ephrin-A4 , EFNA4, EPLG4, LERK4)
Sign In for Pricing
View Details