ZLD2218

Considerable studies confirmed that BRD4 inhibition ameliorated kidney injury and fibrosis, and ZLD2218 exhibited the most potent inhibitory activity against BRD4, with the IC50 value of 107 nM

Product Specifications

CAS Number

[2713974-32-2]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/zld2218.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(C(C3=CC4=C(C=CN4CC5=NC=CC=C5)C=C3)=CN1C)C=CN2

Molecular Formula

C22H18N4O

Molecular Weight

354.40

References & Citations

[1]Tao S, et al. Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis. Eur J Med Chem. 2022 Mar 5;231:114153.