Anticancer agent 28

Anticancer agent 28 shows good antitumor activity in H22 allogeneic mice in vivo. Anticancer agent 28 has inhibitory potency in K562 cells of 50 times than oridonin, and its IC50 value is 0.09 μM.

Product Specifications

CAS Number

2768083-57-2

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-28.html

Solubility

10 mM in DMSO

Smiles

CC1(C)CCC[C@]2(CO3)C1[C@H](O)[C@]3(O)[C@]4(C5=O)C2CC[C@@H](C5=C)[C@H]4OC(/C=C/C6=CC=NC=C6)=O

Molecular Formula

C28H33NO6

Molecular Weight

479.56

References & Citations

[1]Liu J, et al. Identification of new potent anticancer derivatives through simplifying the core structure and modification on their 14- hydroxyl group from oridonin. Eur J Med Chem. 2022 Mar 5;231:114155.