ATR-IN-10

ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC50 value of 2.978 μM.

Product Specifications

CAS Number

[2713577-93-4]

UNSPSC

12352005

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atr-in-10.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1N(C2=C3C=C(C4=CC=CC=C4)C=CC3=NC(C5=CC=CC6=C5C=CN6)=N2)CCOC1

Molecular Formula

C27H24N4O

Molecular Weight

420.51

References & Citations

[1]Bin H, et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187.