SOS1-IN-8
SOS1-IN-8 is a potent SOS1 inhibitor with IC50s of 11.6 and 40.7 nM for SOS1-G12D and SOS1-G12V, respectively (WO2022017339A1, compound 2) [1].
Product Specifications
CAS Number
2759387-92-1
UNSPSC
12352005
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-in-8.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(C(C)=NN=C2N[C@@H](C3=CC=CC(C(F)(CO)F)=C3F)C)=C1)O[C@H]4CCOC4
Molecular Formula
C24H26F3N3O4
Molecular Weight
477.48
References & Citations
[1]Fused pyridazine derivative, preparation method therefor and pharmaceutical use thereof. WO2022017339A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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