SOS1-IN-7
SOS1-IN-7 (compound 18-p1) is a potent SOS1 inhibitor with IC50s of 20 and 67 nM for SOS1-G12D and SOS1-G12V, respectively[1].
Product Specifications
CAS Number
2755415-30-4
UNSPSC
12352005
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-in-7.html
Solubility
10 mM in DMSO
Smiles
C[C@H](C1=C(C(C(F)F)=CC=C1)F)NC2=C3C(NC(C)=N2)=NC(C([C@@]4(CC[C@H](CC4)O)O)=C3)=O
Molecular Formula
C23H25F3N4O3
Molecular Weight
462.46
References & Citations
[1]Pyridine-pyrimidine derivative, preparation method therefor and pharmaceutical use thereof. WO2021249519A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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