SOS1-IN-9

SOS1-IN-9 is a potent SOS1 inhibitor with an IC50 of 116.5 nM for SOS1-KRAS G12C (WO2022028506A1, compound 302) [1].

Product Specifications

CAS Number

[2758900-76-2]

UNSPSC

12352005

Target

Ras; SOS1

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sos1-in-9.html

Solubility

10 mM in DMSO

Smiles

CC1=NC(N[C@@H](C2=CC(N)=CC(C(F)(F)F)=C2)C)=C3CN(CCC3=N1)C4CCOCC4

Molecular Formula

C22H28F3N5O

Molecular Weight

435.49

References & Citations

[1]Sos1 inhibitor, pharmaceutical composition containing same, and use therefor. WO2022028506A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

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