MAT2A-IN-7

MAT2A-IN-7 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-7 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-7 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 24) [1].

Product Specifications

CAS Number

[2756458-77-0]

UNSPSC

12352005

Target

Methionine Adenosyltransferase (MAT)

Type

Reference compound

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mat2a-in-7.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=CC=CC=C2Cl)C3=C(C=CC(C(F)(F)F)=N3)C(NC)=C1OC

Molecular Formula

C17H13ClF3N3O2

Molecular Weight

383.75

References & Citations

[1]Li Zhen, et al. Bicyclic compounds. Patent WO2021254529A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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