MAT2A-IN-5
MAT2A-IN-5 is a potent inhibitor of MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-5 reduces the proliferative activity of MTAP-deficient cancer cells. MAT2A-IN-5 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 1) [1].
Product Specifications
CAS Number
[2756458-55-4]
UNSPSC
12352005
Target
Methionine Adenosyltransferase (MAT)
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mat2a-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC=CC=C2Cl)C3=C(C=CC(C(F)(F)F)=C3)C(NC)=C1
Molecular Formula
C17H12ClF3N2O
Molecular Weight
352.74
References & Citations
[1]Li Zhen, et al. Bicyclic compounds. Patent WO2021254529A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144181/MAT2A-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144181/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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