HGGPPS-IN-2

HGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS) . hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) . hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].

Product Specifications

CAS Number

[2241547-82-8]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hggpps-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC(C2=NC(NC(P(O)(O)=O)P(O)(O)=O)=C3C=CSC3=N2)=C1)NC4=CC=C(C=C4)F

Molecular Formula

C20H18FN5O7P2S

Molecular Weight

553.40

References & Citations

[1]Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65 (3) :2471-2496.