Cas9-IN-2

Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].

Product Specifications

CAS Number

[1030133-34-6]

UNSPSC

12352005

Target

Bacterial; CRISPR/Cas9

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cas9-in-2.html

Solubility

10 mM in DMSO

Smiles

O=S(NC1=NOC(C)=C1)(C2=C(C)N(C(C3=NC(C)=C(C(N4CCC(CC4)C)=O)S3)=C2)C)=O

Molecular Formula

C21H27N5O4S2

Molecular Weight

477.60

References & Citations

[1]Lee SW, et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. J Med Chem. 2022;65 (4) :3266-3305.