A1AR antagonist 2
A1AR antagonist 2 (compound 18h) is a potent A1 adenosine receptor (AR) antagonist with Kis of 1.49, 10.2, and 50.1 nM for hA1, hA2A and hA2B, respectively[1].
Product Specifications
CAS Number
1441961-74-5
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a1ar-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(C2=CC=CC=C2)N=C(N)N=C1C3=CC=CC(O)=C3
Molecular Formula
C17H12N4O
Molecular Weight
288.30
References & Citations
[1]Val C, et al. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists. J Med Chem. 2022;65 (3) :2091-2106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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