A1AR antagonist 2

A1AR antagonist 2 (compound 18h) is a potent A1 adenosine receptor (AR) antagonist with Kis of 1.49, 10.2, and 50.1 nM for hA1, hA2A and hA2B, respectively[1].

Product Specifications

CAS Number

[1441961-74-5]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a1ar-antagonist-2.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(C2=CC=CC=C2)N=C(N)N=C1C3=CC=CC(O)=C3

Molecular Formula

C17H12N4O

Molecular Weight

288.30

References & Citations

[1]Val C, et al. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists. J Med Chem. 2022;65 (3) :2091-2106.