PPARα/δ agonist 1

PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM) . PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM) . PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis[1].

Product Specifications

CAS Number

[2760128-48-9]

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pparα-δ-agonist-1.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(N=CN1C2=CC=C(C=C2)OC(F)(F)F)CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C

Molecular Formula

C22H22F3N3O5

Molecular Weight

465.42

References & Citations

[1]Feng Z, et al. Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2022;65 (3) :2571-2592.