JNK-1-IN-1
JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1[1].
Product Specifications
CAS Number
1262406-02-9
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jnk-1-in-1.html
Solubility
10 mM in DMSO
Smiles
CCCN(C1=NC(C=CC=C2)=C2S1)CC(C=C3)=CC=C3C4=CC=CC=C4C5=NNN=N5
Molecular Formula
C24H22N6S
Molecular Weight
426.54
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Comess KM, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6 (3) :234-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1
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