NSC405640
NSC405640 is a potent inhibitor of the MDM2-p53 interaction. NSC405640 rescues structural p53 mutations. NSC405640 selectively inhibits the growth of cell lines with wild-type p53[1].
Product Specifications
CAS Number
[1135-99-5]
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H315, H319, H335, H400
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc405640.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
Cl[Sn](C1=CC=CC=C1)(C2=CC=CC=C2)Cl
Molecular Formula
C12H10Cl2Sn
Molecular Weight
343.82
Precautions
H301+H311+H331, H315, H319, H335, H400
References & Citations
[1]Chen S, et al. Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell. 2021;39 (2) :225-239.e8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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