Keap1-Nrf2-IN-4

Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC50=2.55 μM) . Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity[1].

Product Specifications

CAS Number

2851480-01-6

UNSPSC

12352005

Target

Apoptosis; E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/keap1-nrf2-in-4.html

Solubility

10 mM in DMSO

Smiles

CCCCCC1=CC=C(C=C1)NC(C2CCN(CC2)C/C=C/C3=CC=CC=C3)=O

Molecular Formula

C26H34N2O

Molecular Weight

390.56

References & Citations

[1]Wang B, et al. Discovery of a cinnamyl piperidine derivative as new neddylation inhibitor for gastric cancer treatment. Eur J Med Chem. 2021; 226:113896.