HDAC8-IN-2
HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs[1].
Product Specifications
CAS Number
2824131-20-4
UNSPSC
12352005
Target
HDAC; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hdac8-in-2.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C(C=C1)C(NO)=O)NC(C2=C3OC4=C(C3=CC=C2)C=CC=C4)=O
Molecular Formula
C21H16N2O5
Molecular Weight
376.36
References & Citations
[1]Ghazy E, et al. Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis. Eur J Med Chem. 2021 Dec 5;225:113745.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6; HDAC8; Schistosome
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