Lu AA47070
Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].
Product Specifications
CAS Number
913842-25-8
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lu-aa47070.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O)OCN1C=CS/C1=N\C(C2=CC(F)=C(NC(CC(C)(C)C)=O)C(F)=C2)=O
Molecular Formula
C17H20F2N3O6PS
Molecular Weight
463.39
References & Citations
[1]Discovery of Phosphoric Acid Mono-{2-[ (E/Z) -4- (3,3-dimethyl-butyrylamino) -3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070) : A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor Antagonist
 J. Med. Chem., Article ASAP
 DOI: 10.1021/jm1008659
 Publication Date (Web) : January 6, 2011|[2]Collins LE, et al. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100 (3) :498-505.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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