MurB-IN-1

MurB-IN-1 (compound 44) is an inhibitor of uridine diphosphate-N-acetylenolpyruvylglucosamine reductase (MurB), with a Kd 3.57 μM. MurB, a target in P. aeruginosa, is an opportunistic infectious agent causing death[1].

Product Specifications

CAS Number

[2883232-46-8]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/murb-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(Cl)=C(C=C1N2N=CC(C(O)=O)=C2C(F)(F)F)Cl

Molecular Formula

C12H7Cl2F3N2O2

Molecular Weight

339.10

References & Citations

[1]Acebrón-García-de-Eulate M, et, al. Discovery of Novel Inhibitors of Uridine Diphosphate- N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. J Med Chem. 2022 Feb 10;65 (3) :2149-2173.