DNA-PK-IN-6
DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6) [1].
Product Specifications
CAS Number
2711810-41-0
UNSPSC
12352005
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dna-pk-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C)C2=C(N3)N1CCCCCC4=CN=C(C=C5C)N4C=C5/N=C3/N=C2
Molecular Formula
C19H21N7O
Molecular Weight
363.42
References & Citations
[1]Xinhai Chen, et al. Macrocyclic compounds as dna-pk inhibitors. Patent WO2021197159A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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