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DNA-PK-IN-5

DNA-PK-IN-5 is a potent inhibitor of DNA-PK. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2) [1].

Product Specifications

CAS Number

[2719736-43-1]

UNSPSC

12352005

Target

DNA-PK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dna-pk-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C1N(N2CC3OC(CC3)C2)C4=NC(NC5=C(C)C=C6N=CC=NC6=C5)=NC=C4N1C

Molecular Formula

C21H22N8O2

Molecular Weight

418.45

References & Citations

[1]Xinhai Chen, et al. Aminopyrimidine compounds and their derivatives as dna-pk inhibitors. Patent WO2021204111A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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