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Tyk2-IN-9

Tyk2-IN-9 (Compound 26) is a selective Tyk-2 inhibitor with IC50s of 0.076 and 1.8 nM for TYK2-JH2 and JAK1-JH2, respectively. Tyk2-IN-9 can be used for the research of inflammatory or autoimmune disease[1].

Product Specifications

CAS Number

2694816-85-6

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tyk2-in-9-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=NN4C=C(N5CC(C(C)O)C5)C=CC4=N3)NC

Molecular Formula

C21H25N9O3

Molecular Weight

451.48

References & Citations

[1]Qiuwen WANG, et al. Tyk-2 inhibitor. WO2021170046A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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