Tyk2-IN-9
Tyk2-IN-9 (Compound 26) is a selective Tyk-2 inhibitor with IC50s of 0.076 and 1.8 nM for TYK2-JH2 and JAK1-JH2, respectively. Tyk2-IN-9 can be used for the research of inflammatory or autoimmune disease[1].
Product Specifications
CAS Number
2694816-85-6
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tyk2-in-9-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=NN4C=C(N5CC(C(C)O)C5)C=CC4=N3)NC
Molecular Formula
C21H25N9O3
Molecular Weight
451.48
References & Citations
[1]Qiuwen WANG, et al. Tyk-2 inhibitor. WO2021170046A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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