RET-IN-13
Product Specifications
UNSPSC Description
RET-IN-13 (compound 1), a quinoline compound, is a potent RET inhibitor with IC50s of 0.5 nM, 0.9 nM for RET (WT) and RET (V804M), respectively. RET-IN-13 has the potential for tumors or intestinal diseases related to abnormal activation of RET research[1].
Target Antigen
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1=CC=C(C2=CN=C3C=C(C(OC)=CC3=C2)OC)N=C1)NC4=C(F)C=C(CN5CCN(CC5)CC)C(C(F)(F)F)=C4
Molecular Weight
611.63
References & Citations
[1]Jiansong Wang, et al. Quinoline compounds. WO2021164742A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144029/RET-IN-13-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144029/
Clinical Information
No Development Reported
CAS Number
2684258-54-4
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