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RET-IN-13

RET-IN-13 (compound 1), a quinoline compound, is a potent RET inhibitor with IC50s of 0.5 nM, 0.9 nM for RET (WT) and RET (V804M), respectively. RET-IN-13 has the potential for tumors or intestinal diseases related to abnormal activation of RET research[1].

Product Specifications

CAS Number

2684258-54-4

UNSPSC

12352005

Target

RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ret-in-13.html

Solubility

10 mM in DMSO

Smiles

O=C(CC1=CC=C(C2=CN=C3C=C(C(OC)=CC3=C2)OC)N=C1)NC4=C(F)C=C(CN5CCN(CC5)CC)C(C(F)(F)F)=C4

Molecular Formula

C32H33F4N5O3

Molecular Weight

611.63

References & Citations

[1]Jiansong Wang, et al. Quinoline compounds. WO2021164742A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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