Pan-Trk-IN-2
Compound cpd-1 is a small molecule Trks inhibitor with good antitumor activity[1].
Product Specifications
CAS Number
2583778-77-0
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-trk-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(NC(N=CN=C3N4)=C3OC(C)(C)C4=O)C=C2
Molecular Formula
C22H18ClF3N6O3
Molecular Weight
506.86
References & Citations
[1]Pan S, et al. Structural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4- (phenylamino) -6H-pyrimido[5,4-b][1,4]oxazin-7 (8H) -one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants. J Med Chem. 2022 Feb 10;65 (3) :2035-2058.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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