18:0 mPEG550 PE (ammonium)

18:0 mPEG550 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

Product Specifications

CAS Number

[474922-77-5]

Product Name Alternative

DSPE-mPEG550 (ammonium) ; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol) -550] (ammonium)

UNSPSC

12352200

Hazard Statement

H302-H315-H319-H331-H336-H351-H361-H372

Target

Biochemical Assay Reagents; Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/18-0-mpeg550-pe-ammonium.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCOP(O)(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOC.N.[n]

Molecular Formula

(C2H4O) nC43H84NO10P.H3N

Molecular Weight

550 (Average)

Precautions

P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Anatoly N Lukyanov, et al. Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits. J Control Release. 2004 Jan 8;94 (1) :187-93.|[2]Cooper A, et al. Osmotic Pressure Enables High-Yield Assembly of Giant Vesicles in Solutions of Physiological Ionic Strengths. Langmuir. 2023 Apr 18;39 (15) :5579-5590.