Indomethacin-d4

Indomethacin-d4 (Indometacin-d4) is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

Product Specifications

CAS Number

[87377-08-0]

Product Name Alternative

Indometacin-d4

UNSPSC

12352005

Hazard Statement

H300, H317, H360

Target

Autophagy; COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Immunology/Inflammation; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Purity

99.78

Solubility

10 mM in DMSO

Smiles

O=C(O)CC1=C(C)N(C(C2=C([2H])C([2H])=C(Cl)C([2H])=C2[2H])=O)C3=C1C=C(OC)C=C3

Molecular Formula

C19H12D4ClNO4

Molecular Weight

361.81

Precautions

H300, H317, H360

References & Citations

[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121 (1) :105-17.|[2]Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8 (1) :3593.