URAT1 inhibitor 2

URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC50 values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout[1].

Product Specifications

CAS Number

[2803951-18-8]

UNSPSC

12352005

Target

URAT1

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/urat1-inhibitor-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C)(SC1=NC2=NC=CC=C2N1CC3=C4C=CC=CC4=C(C=C3)Br)C)O

Molecular Formula

C21H18BrN3O2S

Molecular Weight

456.36

References & Citations

[1]Tong Zhao, et al. Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability. J. Med. Chem. 2022, 65, 5, 4218–4237.