ZL-Pin13
ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells[1].
Product Specifications
CAS Number
2883498-73-3
UNSPSC
12352005
Target
PIN1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zl-pin13.html
Solubility
10 mM in DMSO
Smiles
O=C(CSC12CCN(CC2)C(CCl)=O)N1CC3=CC=C(O3)C4=CC=CC5=C4C=CC=C5
Molecular Formula
C24H23ClN2O3S
Molecular Weight
454.97
References & Citations
[1]Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1) . J Med Chem. 2022;65 (3) :2174-2190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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