ZL-Pin01
ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC50 of 1.33 μM[1].
Product Specifications
CAS Number
1047464-92-5
UNSPSC
12352005
Target
PIN1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zl-pin01.html
Solubility
10 mM in DMSO
Smiles
O=C1CSC2(CCN(C(CCl)=O)CC2)N1CC3=CC=CO3
Molecular Formula
C14H17ClN2O3S
Molecular Weight
328.81
References & Citations
[1]Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1) . J Med Chem. 2022;65 (3) :2174-2190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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