EGFR-IN-40
EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].
Product Specifications
CAS Number
1466445-39-5
UNSPSC
12352005
Target
Btk; EGFR; Itk
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-40.html
Solubility
10 mM in DMSO
Smiles
C=CC(NC1=CC=CC(N2C(C(C)=NC3=CN=C(NC4=CC=C(OC)C=C4)N=C23)=O)=C1)=O
Molecular Formula
C23H20N6O3
Molecular Weight
428.44
References & Citations
[1]Dou Dou, et al. Discovery of Pteridine-7 (8 H) -one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK) . J Med Chem. 2022 Feb 10;65 (3) :2694-2709.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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