FLT3-IN-12
Product Specifications
UNSPSC Description
FLT3-IN-12 is a potent, selective and orally active FLT3 kinase?inhibitor with IC50s of 1.48 nM and 2.87 nM for FLT3-WT and FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold). FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC50 of 0.75 nM)[1].
Target Antigen
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-in-12.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@@H]4CC[C@@H](CC4)N)=N3)C=C2C=CN1C
Molecular Weight
432.44
References & Citations
[1]Lexian Tong, et al. Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. J Med Chem. 2022 Feb 24;65(4):3229-3248.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143895/FLT3-IN-12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143895/
Clinical Information
No Development Reported
CAS Number
2499966-67-3
Curated Selection
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