Keap1-Nrf2-IN-6
Product Specifications
UNSPSC Description
Keap1-Nrf2-IN-6 (compound 64) is a potent and selective Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 41 nM, Kd of 68 nM[1].
Target Antigen
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C1N[C@H](CSCC2=C(C(OC[C@H]1NC([C@@H]3CCCN3C(C)=O)=O)=O)C=CC=C2C4=CC=C(C=C4)C(O)=O)C(N(C)C)=O
Molecular Weight
610.68
References & Citations
[1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143893/Keap1-Nrf2-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143893/
Clinical Information
No Development Reported
Curated Selection
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