Keap1-Nrf2-IN-5
Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1].
Product Specifications
CAS Number
2696272-70-3
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](NC([C@H](NC([C@H]1N(C(C)=O)CCC1)=O)CO2)=O)CSCC3=CC=CC=C3C2=O)N(C)C
Molecular Formula
C23H30N4O6S
Molecular Weight
490.57
References & Citations
[1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65 (4) :3473-3517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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