Keap1-Nrf2-IN-5
Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1].
Product Specifications
CAS Number
2696272-70-3
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](NC([C@H](NC([C@H]1N(C(C)=O)CCC1)=O)CO2)=O)CSCC3=CC=CC=C3C2=O)N(C)C
Molecular Formula
C23H30N4O6S
Molecular Weight
490.57
References & Citations
[1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65 (4) :3473-3517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSH031246 100 µg
Recombinant Human S100A8 Protein (E.coli, His Tag)
Sign In for Pricing
View Details 
BNC882494-500 1x 500 µL
FOLH1 / PSMA (Prostate Epithelial Marker) (FOLH1/2494), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details