AD012
Product Specifications
UNSPSC Description
AD012 is a dual inhibitor of cACE/NEP. AD012 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD012 has the potential for providing the potent antihypertensive and cardioprotective benefits[1].
Target Antigen
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ad012.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCC)N[C@@H](CC2=CC=C(C=C2)O)C(O)=O
Molecular Weight
456.53
References & Citations
[1]Arendse LB, et al. Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J Med Chem. 2022;65(4):3371-3387.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143887/AD012-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143887/
Clinical Information
No Development Reported
CAS Number
3010931-94-6
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