AD012

AD012 is a dual inhibitor of cACE/NEP. AD012 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD012 has the potential for providing the potent antihypertensive and cardioprotective benefits[1].

Product Specifications

CAS Number

[3010931-94-6]

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ad012.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)CCCC)N[C@@H](CC2=CC=C(C=C2)O)C(O)=O

Molecular Formula

C25H32N2O6

Molecular Weight

456.53

References & Citations

[1]Arendse LB, et al. Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J Med Chem. 2022;65 (4) :3371-3387.