JAK1/TYK2-IN-3
JAK1/TYK2-IN-3 is a potent, selective and orally active dual TYK2/JAK1 inhibitor with IC50 values of 6 and 37 nM, respectively. JAK1/TYK2-IN-3 also shows selectively relative to JAK2 (IC50=140 nM) and JAK3 (IC50=362 nM) . JAK1/TYK2-IN-3 shows anti-inflammatory effect by regulating the expression of related TYK2/JAK1-regulated genes, as well as the formation of Th1, Th2, and Th17 cells[1].
Product Specifications
CAS Number
2734918-37-5
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak1-tyk2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C1NCCC12CCN(C3=NC(NC4=CN(C(F)F)N=C4)=NC=C3C)CC2
Molecular Formula
C17H21F2N7O
Molecular Weight
377.39
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1; JAK2; JAK3; Tyk2
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![TR4 Recombinant Rabbit Monoclonal Antibody [JE45-03]](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea8140e/imageurl/ha721372.webp)
TR4 Recombinant Rabbit Monoclonal Antibody [JE45-03]
Tropomyosin 3 (TPM3) (NM_001278188) Human Tagged ORF Clone
Aurora B (Proliferation Marker) (AURKB/1592), Biotin conjugate, 0.1mg/mL
IFluor® 594 PSA™ Imaging Kit with Goat Anti-Mouse IgG
