JAK2/TYK2-IN-1
Product Specifications
UNSPSC Description
JAK2/TYK2-IN-2 is a potent and selective TYK2 inhibitor with IC50 values of 9 and 157 nM for TYK2 and JAK2, respectively. JAK2/TYK2-IN-2 has anti-inflammatory activity[1].
Target Antigen
JAK
Type
Inhibitory Antibodies
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak2-tyk2-in-1.html
Solubility
10 mM in DMSO
Smiles
N#CCCN1N=CC(C2=NC(NC3=CC4=C(N(S(=O)(C(F)(F)F)=O)C=C4)C=C3)=NC=C2F)=C1
Molecular Weight
479.41
References & Citations
[1]Zhang C, et al. Discovery of 3-(4-(2-((1H-Indol-5-yl) amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl) propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2021; 64(4):1966-1988.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143884/JAK2-TYK2-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143884/
Clinical Information
No Development Reported
CAS Number
2613434-12-9
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