JAK2/TYK2-IN-1

JAK2/TYK2-IN-2 is a potent and selective TYK2 inhibitor with IC50 values of 9 and 157 nM for TYK2 and JAK2, respectively. JAK2/TYK2-IN-2 has anti-inflammatory activity[1].

Product Specifications

CAS Number

[2613434-12-9]

UNSPSC

12352005

Target

JAK

Type

Inhibitory Antibodies

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jak2-tyk2-in-1.html

Solubility

10 mM in DMSO

Smiles

N#CCCN1N=CC(C2=NC(NC3=CC4=C(N(S(=O)(C(F)(F)F)=O)C=C4)C=C3)=NC=C2F)=C1

Molecular Formula

C19H13F4N7O2S

Molecular Weight

479.41

References & Citations

[1]Zhang C, et al. Discovery of 3- (4- (2- ((1H-Indol-5-yl) amino) -5-fluoropyrimidin-4-yl) -1H-pyrazol-1-yl) propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2021; 64 (4) :1966-1988.