MRGPRX1 agonist 4

MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain[1].

Product Specifications

CAS Number

[2764889-60-1]

UNSPSC

12352005

Target

Mas-related G-protein-coupled Receptor (MRGPR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mrgprx1-agonist-4.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C1=C(C2=CC=C(C(Cl)=C2)Cl)C3=C(N=CN=C3OC4=C(C=CC=C4)OC(F)(F)F)S1)C

Molecular Formula

C23H17Cl2F3N2O2S

Molecular Weight

513.36

References & Citations

[1]Berhane I, et al. Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1) . J Med Chem. 2022;65 (4) :3218-3228.