MRGPRX1 agonist 3
MRGPRX1 agonist 3 (compound 1f) is a potent Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.22 μM. MRGPRX1 agonist 3 can be used for researching neuropathic pain[1].
Product Specifications
CAS Number
2764889-51-0
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrgprx1-agonist-3.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C2=C(N=CN=C2OC3=C(C=CC=C3)F)S1)C
Molecular Formula
C14H11FN2OS
Molecular Weight
274.31
References & Citations
[1]Berhane I, et al. Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1) . J Med Chem. 2022;65 (4) :3218-3228.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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