NN-390

NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB) . NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma) [1].

Product Specifications

CAS Number

[2490284-25-6]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nn-390.html

Solubility

10 mM in DMSO

Smiles

O=C(NO)C1=CC=C(CN(C(C)C)S(=O)(C2=CC(F)=C(F)C(F)=C2F)=O)C=C1

Molecular Formula

C17H16F4N2O4S

Molecular Weight

420.38

References & Citations

[1]Nawar N, Bukhari S, Adile AA, et al. Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma. J Med Chem. 2022;65 (4) :3193-3217.