NN-390
NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB) . NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma) [1].
Product Specifications
CAS Number
[2490284-25-6]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nn-390.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(CN(C(C)C)S(=O)(C2=CC(F)=C(F)C(F)=C2F)=O)C=C1
Molecular Formula
C17H16F4N2O4S
Molecular Weight
420.38
References & Citations
[1]Nawar N, Bukhari S, Adile AA, et al. Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma. J Med Chem. 2022;65 (4) :3193-3217.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC2; HDAC3; HDAC6; HDAC8
Available Sizes
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